He succeeded Patriarch Gerasimos II of Alexandria, and was faced with the problem of the parallel election of another Patriarch of Alexandria, Kosmas of Klavdiopolis, by the Ecumenical Patriachate, who also received a Sultan’s notice in support of the latter. Two years later the new Ecumenical Patriarch Kyprianos II accepted Samuel as the proper Patriarch of Alexandria. He fell asleep in September 1723.