He was born n Patmos . His general church activities are not known. He renovated the ancient Holy Monastery of St George in Old Cairo and re-organized the Patriarchal Library. Following the French conquest of Egypt under the leadership of Napoleon Bonaparte, Patriarch Parthenios II withstood enormous persecution by the Arabs and was forced to seek refuge first in Rahitio and then in Rhodes where he fell asleep on 9th September 1805.