He was the Chancellor of the Patriarchate of Alexandria during the Patriarchal tenure of Sylvester, his predecessor, whom he succeeded to the Patriarchal Throne. He faced overwhelming financial debts of the Church to the Sultan. He also stood against the activities of proselytism by the Jesuit monks against the Orthodox Christians of Egypt.  He participated in the work of the Local Synod in 1593 in Constantinople , on the ratification of the establishment of a Russian Patriarchate. He tried to bring about the unity of the Copts of Egypt and Ethiopia ( Abyssinia ) with the Orthodox, but also saw to more general pastoral, inter-Christian and inter-Church issues. He was also the “Supervisor” of the Ecumenical Patriarchate. He died aged 52 and is honoured as a Saint of the Church.